2nnz: Difference between revisions

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[[Image:2nnz.jpg|left|200px]]
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[[Image:2nnz.png|left|200px]]


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{{STRUCTURE_2nnz|  PDB=2nnz  |  SCENE=  }}  
{{STRUCTURE_2nnz|  PDB=2nnz  |  SCENE=  }}  


'''Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus'''
===Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus===




==Overview==
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AF2241 is a hypothetical protein from Archaeoglobus fulgidus and it belongs to the PFam domain of unknown function 369 (DUF369). NMR structural determination reveals that AF2241 adopts a cyclophilin-like fold, with a beta-barrel core composed of eight beta-strands, one alpha-helix, and one 3(10) helix located at each end of the barrel. The protein displays a high structural similarity to TM1367, another member of DUF369 whose structure has been determined recently by X-ray crystallography. Structural similarity search shows that AF2241 also has a high similarity to human cyclophilin A, however, sequence alignment and electrostatic potential analysis reveal that the residues in the PPIase catalytic site of human cyclophilin A are not conserved in AF2241 or TM1367. Instead, a putative active site of AF2241 maps to a negatively charged pocket composed of 9 conserved residues. Our results suggest that although AF2241 adopts the same fold as the human cyclophilin A, it may have distinct biological function.
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{{ABSTRACT_PUBMED_17610131}}


==About this Structure==
==About this Structure==
2NNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].  
2NNZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NNZ OCA].  


==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
[[Category: Unknown function]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:41:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:26:26 2008''

Revision as of 05:26, 29 July 2008

File:2nnz.png

Template:STRUCTURE 2nnz

Solution structure of the hypothetical protein AF2241 from Archaeoglobus fulgidus

Template:ABSTRACT PUBMED 17610131

About this Structure

2NNZ is a Single protein structure of sequence from Archaeoglobus fulgidus. Full experimental information is available from OCA.

Reference

Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold., Ai X, Li L, Semesi A, Yee A, Arrowsmith CH, Li SS, Choy WY, J Biomol NMR. 2007 Aug;38(4):353-8. Epub 2007 Jul 4. PMID:17610131

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