2bdl: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
Line 1: Line 1:
[[Image:2bdl.gif|left|200px]]
{{Seed}}
[[Image:2bdl.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bdl|  PDB=2bdl  |  SCENE=  }}  
{{STRUCTURE_2bdl|  PDB=2bdl  |  SCENE=  }}  


'''Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor'''
===Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor===




==Overview==
<!--
Starting from a potent pantolactone ketoamide cathepsin K inhibitor discovered from structural screening, conversion of the lactone scaffold to a pyrrolidine scaffold allowed exploration of the S(3) subsite of cathepsin K. Manipulation of P3 and P1' groups afforded potent inhibitors with drug-like properties.
The line below this paragraph, {{ABSTRACT_PUBMED_16376075}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16376075 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16376075}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Cato]]
[[Category: Cato]]
[[Category: Cysteine protease]]
[[Category: Cysteine protease]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:08:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:30:15 2008''

Revision as of 05:30, 29 July 2008

File:2bdl.png

Template:STRUCTURE 2bdl

Cathepsin K complexed with a pyrrolidine ketoamide-based inhibitor

Template:ABSTRACT PUBMED 16376075

About this Structure

2BDL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors., Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Ray JA, Samano V, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2006 Mar 15;16(6):1735-9. Epub 2006 Jan 11. PMID:16376075

Page seeded by OCA on Tue Jul 29 08:30:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA