2pzy: Difference between revisions

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[[Image:2pzy.jpg|left|200px]]
{{Seed}}
[[Image:2pzy.png|left|200px]]


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{{STRUCTURE_2pzy|  PDB=2pzy  |  SCENE=  }}  
{{STRUCTURE_2pzy|  PDB=2pzy  |  SCENE=  }}  


'''Structure of MK2 Complexed with Compound 76'''
===Structure of MK2 Complexed with Compound 76===




==Overview==
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The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10 nM, as measured in a DELFIA assay. An X-ray crystal structure reveals that they bind in a region near the p-loop and the hinge region of MK2a.
The line below this paragraph, {{ABSTRACT_PUBMED_17576063}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17576063 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17576063}}


==About this Structure==
==About this Structure==
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[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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