3ctj: Difference between revisions

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[[Image:3ctj.jpg|left|200px]]
{{Seed}}
[[Image:3ctj.png|left|200px]]


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{{STRUCTURE_3ctj|  PDB=3ctj  |  SCENE=  }}  
{{STRUCTURE_3ctj|  PDB=3ctj  |  SCENE=  }}  


'''Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor'''
===Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor===




==Overview==
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A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the discovery of compounds 3b and 20b, which demonstrated favorable pharmacokinetic properties in mice and significant antitumor activity in a human gastric carcinoma xenograft model.
The line below this paragraph, {{ABSTRACT_PUBMED_18479916}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18479916}}


==Disease==
==Disease==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:50:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:32:23 2008''
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