2jvb: Difference between revisions

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[[Image:2jvb.jpg|left|200px]]
{{Seed}}
[[Image:2jvb.png|left|200px]]


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{{STRUCTURE_2jvb|  PDB=2jvb  |  SCENE=  }}  
{{STRUCTURE_2jvb|  PDB=2jvb  |  SCENE=  }}  


'''Solution Structure of Catalytic Domain of yDcp2'''
===Solution Structure of Catalytic Domain of yDcp2===




==Overview==
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Cap hydrolysis by Dcp2 is a critical step in several eukaryotic mRNA decay pathways. Processing requires access to cap-proximal nucleotides and the coordinated assembly of a decapping mRNP, but the mechanism of substrate recognition and regulation by protein interactions have remained elusive. Using NMR spectroscopy and kinetic analyses, we show that yeast Dcp2 resolves interactions with the cap and RNA body using a bipartite surface that forms a channel intersecting the catalytic and regulatory Dcp1-binding domains. The interaction with cap is weak but specific and requires binding of the RNA body to a dynamic interface. The catalytic step is stimulated by Dcp1 and its interaction domain, likely through a substrate-induced conformational change. Thus, activation of the decapping mRNP is restricted by access to 5'-proximal nucleotides, a feature that could act as a checkpoint in mRNA metabolism.
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{{ABSTRACT_PUBMED_18280238}}


==About this Structure==
==About this Structure==
2JVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVB OCA].  
2JVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JVB OCA].  


==Reference==
==Reference==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:19:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:39:32 2008''

Revision as of 05:39, 29 July 2008

File:2jvb.png

Template:STRUCTURE 2jvb

Solution Structure of Catalytic Domain of yDcp2

Template:ABSTRACT PUBMED 18280238

About this Structure

2JVB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2., Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD, Mol Cell. 2008 Feb 15;29(3):324-36. PMID:18280238

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