2osz: Difference between revisions

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[[Image:2osz.gif|left|200px]]
{{Seed}}
[[Image:2osz.png|left|200px]]


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{{STRUCTURE_2osz|  PDB=2osz  |  SCENE=  }}  
{{STRUCTURE_2osz|  PDB=2osz  |  SCENE=  }}  


'''Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding'''
===Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding===




==Overview==
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The nucleoporins Nup58 and Nup45 are part of the central transport channel of the nuclear pore complex, which is thought to have a flexible diameter. In the crystal structure of an alpha-helical region of mammalian Nup58/45, we identified distinct tetramers, each consisting of two antiparallel hairpin dimers. The intradimeric interface is hydrophobic, whereas dimer-dimer association occurs through large hydrophilic residues. These residues are laterally displaced in various tetramer conformations, which suggests an intermolecular sliding by 11 angstroms. We propose that circumferential sliding plays a role in adjusting the diameter of the central transport channel.
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{{ABSTRACT_PUBMED_17379812}}


==About this Structure==
==About this Structure==
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[[Category: Nucleoporin]]
[[Category: Nucleoporin]]
[[Category: Structure]]
[[Category: Structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:35:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:41:21 2008''

Revision as of 05:41, 29 July 2008

File:2osz.png

Template:STRUCTURE 2osz

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding

Template:ABSTRACT PUBMED 17379812

About this Structure

2OSZ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding., Melcak I, Hoelz A, Blobel G, Science. 2007 Mar 23;315(5819):1729-32. PMID:17379812

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