1o08: Difference between revisions

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[[Image:1o08.gif|left|200px]]
{{Seed}}
[[Image:1o08.png|left|200px]]


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{{STRUCTURE_1o08|  PDB=1o08  |  SCENE=  }}  
{{STRUCTURE_1o08|  PDB=1o08  |  SCENE=  }}  


'''Structure of Pentavalent Phosphorous Intermediate of an Enzyme Catalyzed Phosphoryl transfer Reaction observed on cocrystallization with Glucose 1-phosphate'''
===Structure of Pentavalent Phosphorous Intermediate of an Enzyme Catalyzed Phosphoryl transfer Reaction observed on cocrystallization with Glucose 1-phosphate===




==Overview==
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Enzymes provide enormous rate enhancements, unmatched by any other type of catalyst. The stabilization of high-energy states along the reaction coordinate is the crux of the catalytic power of enzymes. We report the atomic-resolution structure of a high-energy reaction intermediate stabilized in the active site of an enzyme. Crystallization of phosphorylated beta-phosphoglucomutase in the presence of the Mg(II) cofactor and either of the substrates glucose 1-phosphate or glucose 6-phosphate produced crystals of the enzyme-Mg(II)-glucose 1,6-(bis)phosphate complex, which diffracted x-rays to 1.2 and 1.4 angstroms, respectively. The structure reveals a stabilized pentacovalent phosphorane formed in the phosphoryl transfer from the C(1)O of glucose 1,6-(bis)phosphate to the nucleophilic Asp8 carboxylate.
The line below this paragraph, {{ABSTRACT_PUBMED_12637673}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_12637673}}


==About this Structure==
==About this Structure==
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[[Category: Pentavalent phosphate intermediate]]
[[Category: Pentavalent phosphate intermediate]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:12:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:46:02 2008''
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