1t5m: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1t5m.gif|left|200px]]
{{Seed}}
[[Image:1t5m.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1t5m|  PDB=1t5m  |  SCENE=  }}  
{{STRUCTURE_1t5m|  PDB=1t5m  |  SCENE=  }}  


'''Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin'''
===Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin===




==Overview==
<!--
Daptomycin is a cyclic anionic lipopeptide antibiotic recently approved for the treatment of complicated skin infections (Cubicin). Its function is dependent on calcium (as Ca2+). Circular dichroism spectroscopy indicated that daptomycin experienced two structural transitions: a transition upon interaction of daptomycin with Ca2+, and a further transition upon interaction with Ca2+ and the bacterial acidic phospholipid, phosphatidyl glycerol. The Ca2+-dependent insertion of daptomycin into model membranes promoted mild and more pronounced perturbations as assessed by the increase of lipid flip-flop and membrane leakage, respectively. The NMR structure of daptomycin indicated that Ca2+ induced a conformational change in daptomycin that increased its amphipathicity. These results are consistent with the hypothesis that the association of Ca2+ with daptomycin permits it to interact with bacterial membranes with effects that are similar to those of the cationic antimicrobial peptides.
The line below this paragraph, {{ABSTRACT_PUBMED_15271353}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15271353 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15271353}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5M OCA].  


==Reference==
==Reference==
Line 30: Line 34:
[[Category: Daptomycin]]
[[Category: Daptomycin]]
[[Category: Drug]]
[[Category: Drug]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:33:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:55:21 2008''
Retrieved from "https://proteopedia.org/1t5m"