3ccn: Difference between revisions

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[[Image:3ccn.jpg|left|200px]]
{{Seed}}
[[Image:3ccn.png|left|200px]]


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{{STRUCTURE_3ccn|  PDB=3ccn  |  SCENE=  }}  
{{STRUCTURE_3ccn|  PDB=3ccn  |  SCENE=  }}  


'''X-ray structure of c-Met with triazolopyridazine inhibitor.'''
===X-ray structure of c-Met with triazolopyridazine inhibitor.===




==Overview==
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Tumorigenesis is a multistep process in which oncogenes play a key role in tumor formation, growth, and maintenance. MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. Deregulated signaling in the c-Met pathway has been observed in multiple tumor types. Herein we report the discovery of potent and selective triazolopyridazine small molecules that inhibit c-Met activity.
The line below this paragraph, {{ABSTRACT_PUBMED_18426196}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18426196 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18426196}}


==Disease==
==Disease==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:37:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:55:38 2008''
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