1nmf: Difference between revisions

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[[Image:1nmf.jpg|left|200px]]
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[[Image:1nmf.png|left|200px]]


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{{STRUCTURE_1nmf|  PDB=1nmf  |  SCENE=  }}  
{{STRUCTURE_1nmf|  PDB=1nmf  |  SCENE=  }}  


'''MAJOR COLD-SHOCK PROTEIN, NMR, 20 STRUCTURES'''
===MAJOR COLD-SHOCK PROTEIN, NMR, 20 STRUCTURES===




==Overview==
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The cold-shock domain (CSD) is found in many eukaryotic transcriptional factors and is responsible for the specific binding to DNA of a cis-element called the Y-box. The same domain exists in the sequence of the Xenopus RNA-binding proteins FRG Y1 and FRG Y2 (refs 1, 3). The major cold-shock proteins of Escherichia coli (CS7.4) and B. subtilis (CspB) have sequences that are more than 40 per cent identical to the cold-shock domain. We present here the three-dimensional structure of CspB determined by nuclear magnetic resonance spectroscopy. The 67-residue protein consists of an antiparallel five-stranded beta-barrel with strands connected by turns and loops. The structure resembles that of staphylococcal nuclease and the gene-5 single-stranded-DNA-binding protein. A three-stranded beta-sheet, which contains the conserved RNA-binding motif RNP1 as well as a motif similar to RNP2 in two neighbouring antiparallel beta-strands, has basic and aromatic residues at its surface which could serve as a binding site for single-stranded DNA. CspB binds to single-stranded DNA in gel retardation experiments.
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{{ABSTRACT_PUBMED_8321289}}


==About this Structure==
==About this Structure==
1NMF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NMF OCA].  
1NMF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NMF OCA].  


==Reference==
==Reference==
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[[Category: Cold shock protein]]
[[Category: Cold shock protein]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:42:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:05:08 2008''

Revision as of 06:05, 29 July 2008

File:1nmf.png

Template:STRUCTURE 1nmf

MAJOR COLD-SHOCK PROTEIN, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 8321289

About this Structure

1NMF is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

Structure in solution of the major cold-shock protein from Bacillus subtilis., Schnuchel A, Wiltscheck R, Czisch M, Herrler M, Willimsky G, Graumann P, Marahiel MA, Holak TA, Nature. 1993 Jul 8;364(6433):169-71. PMID:8321289

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