1r74: Difference between revisions

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[[Image:1r74.~~jpg~~|left|200px]]

[[Image:1r74.png|left|200px]]

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~~'''~~Crystal Structure of Human Glycine N-Methyltransferase~~'''~~

===Crystal Structure of Human Glycine N-Methyltransferase===

~~==Overview==~~

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~~Glycine N-methyltransferases (GNMTs) from three mammalian sources were compared with respect to their crystal structures and kinetic parameters.~~ The crystal structure for the rat enzyme was published previously. Human and mouse GNMT were expressed in Escherichia coli in order to determine their crystal structures. Mouse GNMT was crystallized in two crystal forms, ~~a monoclinic form and a tetragonal form. Comparison of~~ the ~~three structures reveals subtle differences, which may relate~~ to the ~~different kinetic properties of the enzymes~~.~~The flexible character of several loops surrounding the active site~~, ~~along with an analysis of the active site boundaries, indicates that the observed conformations of human and mouse GNMTs are more open than that of the rat enzyme. There~~ is ~~an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of~~ the ~~respective enzymes~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15340920}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15340920 is the PubMed ID number.

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==Disease==

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[[Category: Glycine n-methyltransferase]]

[[Category: Human]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 07~~:09:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:06:34 2008''

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-[[Image:1r74.jpg|left|200px]]
+{{Seed}}
+[[Image:1r74.png|left|200px]]
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 {{STRUCTURE_1r74|  PDB=1r74  |  SCENE=  }}
-'''Crystal Structure of Human Glycine N-Methyltransferase'''
+===Crystal Structure of Human Glycine N-Methyltransferase===
-==Overview==
+<!--
-Glycine N-methyltransferases (GNMTs) from three mammalian sources were compared with respect to their crystal structures and kinetic parameters. The crystal structure for the rat enzyme was published previously. Human and mouse GNMT were expressed in Escherichia coli in order to determine their crystal structures. Mouse GNMT was crystallized in two crystal forms, a monoclinic form and a tetragonal form. Comparison of the three structures reveals subtle differences, which may relate to the different kinetic properties of the enzymes.The flexible character of several loops surrounding the active site, along with an analysis of the active site boundaries, indicates that the observed conformations of human and mouse GNMTs are more open than that of the rat enzyme. There is an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of the respective enzymes.
+The line below this paragraph, {{ABSTRACT_PUBMED_15340920}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15340920 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15340920}}
 ==Disease==
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 [[Category: Glycine n-methyltransferase]]
 [[Category: Human]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:09:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:06:34 2008''