2bm6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:2bm6.gif|left|200px]]
{{Seed}}
[[Image:2bm6.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bm6|  PDB=2bm6  |  SCENE=  }}  
{{STRUCTURE_2bm6|  PDB=2bm6  |  SCENE=  }}  


'''THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.'''
===THE STRUCTURE OF MFPA (RV3361C, C2221 CRYSTAL FORM). THE PENTAPEPTIDE REPEAT PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS FOLDS AS A RIGHT-HANDED QUADRILATERAL BETA-HELIX.===




==Overview==
<!--
Fluoroquinolones are gaining increasing importance in the treatment of tuberculosis. The expression of MfpA, a member of the pentapeptide repeat family of proteins from Mycobacterium tuberculosis, causes resistance to ciprofloxacin and sparfloxacin. This protein binds to DNA gyrase and inhibits its activity. Its three-dimensional structure reveals a fold, which we have named the right-handed quadrilateral beta helix, that exhibits size, shape, and electrostatic similarity to B-form DNA. This represents a form of DNA mimicry and explains both its inhibitory effect on DNA gyrase and fluoroquinolone resistance resulting from the protein's expression in vivo.
The line below this paragraph, {{ABSTRACT_PUBMED_15933203}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15933203 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15933203}}


==About this Structure==
==About this Structure==
Line 33: Line 37:
[[Category: Pentapeptide repeat protein,fluroquinolone resistance]]
[[Category: Pentapeptide repeat protein,fluroquinolone resistance]]
[[Category: Right-handed quadrilateral beta-helix]]
[[Category: Right-handed quadrilateral beta-helix]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:28:46 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:07:07 2008''
Retrieved from "https://proteopedia.org/2bm6"