2phx: Difference between revisions

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[[Image:2phx.jpg|left|200px]]
{{Seed}}
[[Image:2phx.png|left|200px]]


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{{STRUCTURE_2phx|  PDB=2phx  |  SCENE=  }}  
{{STRUCTURE_2phx|  PDB=2phx  |  SCENE=  }}  


'''Pterocarpus angolensis lectin (PAL) in complex with Man-5'''
===Pterocarpus angolensis lectin (PAL) in complex with Man-5===




==Overview==
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The crystal structure of Pterocarpus angolensis seed lectin is presented in complex with a series of high mannose (Man) oligosaccharides ranging from Man-5 to Man-9. Despite that several of the nine Man residues of Man-9 have the potential to bind in the monosaccharide-binding site, all oligomannoses are bound in the same unique way, employing the tetrasaccharide sequence Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-. Isothermal titration calorimetry titration experiments using Man-5, Man-9, and the Man-9-containing glycoprotein soybean (Glycine max) agglutinin as ligands confirm the monovalence of Man-9 and show a 4-times higher affinity for Man-9 when it is presented to P. angolensis seed lectin in a glycoprotein context.
The line below this paragraph, {{ABSTRACT_PUBMED_17556509}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17556509 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17556509}}


==About this Structure==
==About this Structure==
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[[Category: High mannose]]
[[Category: High mannose]]
[[Category: Lectin]]
[[Category: Lectin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:08:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:15:35 2008''
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