2hj9: Difference between revisions

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[[Image:2hj9.gif|left|200px]]
{{Seed}}
[[Image:2hj9.png|left|200px]]


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{{STRUCTURE_2hj9|  PDB=2hj9  |  SCENE=  }}  
{{STRUCTURE_2hj9|  PDB=2hj9  |  SCENE=  }}  


'''Crystal structure of the Autoinducer-2-bound form of Vibrio harveyi LuxP complexed with the periplasmic domain of LuxQ'''
===Crystal structure of the Autoinducer-2-bound form of Vibrio harveyi LuxP complexed with the periplasmic domain of LuxQ===




==Overview==
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Bacteria sense their environment using receptors of the histidine sensor kinase family, but how kinase activity is regulated by ligand binding is not well understood. Autoinducer-2 (AI-2), a secreted signaling molecule originally identified in studies of the marine bacterium Vibrio harveyi, regulates quorum-sensing responses and allows communication between different bacterial species. AI-2 signal transduction in V. harveyi requires the integral membrane receptor LuxPQ, comprised of periplasmic binding protein (LuxP) and histidine sensor kinase (LuxQ) subunits. Combined X-ray crystallographic and functional studies show that AI-2 binding causes a major conformational change within LuxP, which in turn stabilizes a quaternary arrangement in which two LuxPQ monomers are asymmetrically associated. We propose that formation of this asymmetric quaternary structure is responsible for repressing the kinase activity of both LuxQ subunits and triggering the transition of V. harveyi into quorum-sensing mode.
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{{ABSTRACT_PUBMED_16990134}}


==About this Structure==
==About this Structure==
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[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
[[Category: Quorum sensing]]
[[Category: Quorum sensing]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:21:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:27:55 2008''

Revision as of 06:28, 29 July 2008

File:2hj9.png

Template:STRUCTURE 2hj9

Crystal structure of the Autoinducer-2-bound form of Vibrio harveyi LuxP complexed with the periplasmic domain of LuxQ

Template:ABSTRACT PUBMED 16990134

About this Structure

2HJ9 is a Protein complex structure of sequences from Vibrio harveyi. Full crystallographic information is available from OCA.

Reference

Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing., Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM, Cell. 2006 Sep 22;126(6):1095-108. PMID:16990134

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