2eu2: Difference between revisions

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[[Image:2eu2.gif|left|200px]]
{{Seed}}
[[Image:2eu2.png|left|200px]]


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{{STRUCTURE_2eu2|  PDB=2eu2  |  SCENE=  }}  
{{STRUCTURE_2eu2|  PDB=2eu2  |  SCENE=  }}  


'''Human Carbonic Anhydrase II in complex with novel inhibitors'''
===Human Carbonic Anhydrase II in complex with novel inhibitors===




==Overview==
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Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. The structures presented here reveal that these spacer groups allow novel binding modes for the thiadiazole moiety compared with conventional CAIs.
The line below this paragraph, {{ABSTRACT_PUBMED_16820676}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16820676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16820676}}


==Disease==
==Disease==
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[[Category: Silverman, D N.]]
[[Category: Silverman, D N.]]
[[Category: Carbonic anhydrase ii proton transfer inhibitor]]
[[Category: Carbonic anhydrase ii proton transfer inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:06:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:35:03 2008''
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