1t2l: Difference between revisions

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[[Image:1t2l.jpg|left|200px]]
{{Seed}}
[[Image:1t2l.png|left|200px]]


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{{STRUCTURE_1t2l|  PDB=1t2l  |  SCENE=  }}  
{{STRUCTURE_1t2l|  PDB=1t2l  |  SCENE=  }}  


'''Three Crystal Structures of Human Coactosin-like Protein'''
===Three Crystal Structures of Human Coactosin-like Protein===




==Overview==
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Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. We determined the crystal structures of human coactosin-like protein by multi-wavelength anomalous dispersion method. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.
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{{ABSTRACT_PUBMED_15522287}}


==About this Structure==
==About this Structure==
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[[Category: Wei, Z.]]
[[Category: Wei, Z.]]
[[Category: Beta-sheet]]
[[Category: Beta-sheet]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:26:17 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:42:13 2008''

Revision as of 06:42, 29 July 2008

File:1t2l.png

Template:STRUCTURE 1t2l

Three Crystal Structures of Human Coactosin-like Protein

Template:ABSTRACT PUBMED 15522287

About this Structure

1T2L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human coactosin-like protein., Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W, J Mol Biol. 2004 Nov 19;344(2):317-23. PMID:15522287

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