1tf5: Difference between revisions

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[[Image:1tf5.jpg|left|200px]]
{{Seed}}
[[Image:1tf5.png|left|200px]]


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{{STRUCTURE_1tf5|  PDB=1tf5  |  SCENE=  }}  
{{STRUCTURE_1tf5|  PDB=1tf5  |  SCENE=  }}  


'''Crystal structure of SecA in an open conformation from Bacillus Subtilis'''
===Crystal structure of SecA in an open conformation from Bacillus Subtilis===




==Overview==
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The ATPase SecA mediates the posttranslational translocation of a wide range of polypeptide substrates through the SecY channel in the cytoplasmic membrane of bacteria. We have determined the crystal structure of a monomeric form of Bacillus subtilis SecA at a 2.2-A resolution. A comparison with the previously determined structures of SecA reveals a nucleotide-independent, large conformational change that opens a deep groove similar to that in other proteins that interact with diverse polypeptides. We propose that the open form of SecA represents an activated state.
The line below this paragraph, {{ABSTRACT_PUBMED_15256599}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_15256599}}


==About this Structure==
==About this Structure==
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[[Category: Secretion]]
[[Category: Secretion]]
[[Category: Translocation]]
[[Category: Translocation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:52:42 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:47:08 2008''
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