2b5d: Difference between revisions

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[[Image:2b5d.gif|left|200px]]
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{{STRUCTURE_2b5d|  PDB=2b5d  |  SCENE=  }}  
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'''Crystal structure of the novel alpha-amylase AmyC from Thermotoga maritima'''
===Crystal structure of the novel alpha-amylase AmyC from Thermotoga maritima===




==Overview==
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alpha-Amylases are essential enzymes in alpha-glucan metabolism and catalyse the hydrolysis of long sugar polymers such as amylose and starch. The crystal structure of a previously unidentified amylase (AmyC) from the hyperthermophilic organism Thermotoga maritima was determined at 2.2 Angstroms resolution by means of MAD. AmyC lacks sequence similarity to canonical alpha-amylases, which belong to glycosyl hydrolase families 13, 70 and 77, but exhibits significant similarity to a group of as yet uncharacterized proteins in COG1543 and is related to glycerol hydrolase family 57 (GH-57). AmyC reveals features that are characteristic of alpha-amylases, such as a distorted TIM-barrel structure formed by seven beta-strands and alpha-helices (domain A), and two additional but less well conserved domains. The latter are domain B, which contains three helices inserted in the TIM-barrel after beta-sheet 2, and domain C, a five-helix region at the C-terminus. Interestingly, despite moderate sequence homology, structure comparison revealed significant similarities to a member of GH-57 with known three-dimensional structure, Thermococcus litoralis 4-glucanotransferase, and an even higher similarity to a structure of an enzyme of unknown function from Thermus thermophilus.
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{{ABSTRACT_PUBMED_16510973}}


==About this Structure==
==About this Structure==
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[[Category: Ficner, R.]]
[[Category: Ficner, R.]]
[[Category: Liebl, W.]]
[[Category: Liebl, W.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:52:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:47:55 2008''

Revision as of 06:47, 29 July 2008

File:2b5d.png

Template:STRUCTURE 2b5d

Crystal structure of the novel alpha-amylase AmyC from Thermotoga maritima

Template:ABSTRACT PUBMED 16510973

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the novel alpha-amylase AmyC from Thermotoga maritima., Dickmanns A, Ballschmiter M, Liebl W, Ficner R, Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):262-70. Epub 2006, Feb 22. PMID:16510973

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