2c7h: Difference between revisions

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[[Image:2c7h.gif|left|200px]]
{{Seed}}
[[Image:2c7h.png|left|200px]]


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{{STRUCTURE_2c7h|  PDB=2c7h  |  SCENE=  }}  
{{STRUCTURE_2c7h|  PDB=2c7h  |  SCENE=  }}  


'''SOLUTION NMR STRUCTURE OF THE DWNN DOMAIN FROM HUMAN RBBP6'''
===SOLUTION NMR STRUCTURE OF THE DWNN DOMAIN FROM HUMAN RBBP6===




==Overview==
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BACKGROUND: RBBP6 is a 250 kDa splicing-associated protein that has been identified as an E3 ligase due to the presence of a RING finger domain. In humans and mice it interacts with both p53 and Rb, and plays a role in the induction of apoptosis and regulation of the cell cycle. RBBP6 has recently been shown to be highly up-regulated in oesophageal cancer, and to be a promising target for immunotherapy against the disease. RESULTS: We show here using heteronuclear NMR that the N-terminal 81 amino acids of RBBP6 constitute a novel ubiquitin-like domain, which we have called the DWNN domain. The domain lacks conserved equivalents of K48 and K63, although the equivalents of K6 and K29 are highly, although not absolutely, conserved. The di-glycine motif that is characteristic of proteins involved in ubiquitination is found in the human and mouse form of the domain, although it is not present in all organisms. It forms part of a three-domain form of RBBP6 containing the DWNN domain, a zinc knuckle and a RING finger domain, which is found in all eukaryotic genomes so far examined, in the majority of cases at single copy number. The domain is also independently expressed in vertebrates as a single domain protein. CONCLUSION: DWNN is a novel ubiquitin-like domain found only at the N-terminus of the RBBP6 family of splicing-associated proteins. The ubiquitin-like structure of the domain greatly increases the likelihood that RBBP6 functions through some form of ubiquitin-like modification. Furthermore, the fact that the DWNN domain is independently expressed in higher vertebrates leads us to propose that the domain may itself function as a novel ubiquitin-like modifier of other proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16396680 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16396680}}


==About this Structure==
==About this Structure==
2C7H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7H OCA].  
2C7H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7H OCA].  


==Reference==
==Reference==
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[[Category: Splicing-associated]]
[[Category: Splicing-associated]]
[[Category: Ubiquitin-like protein]]
[[Category: Ubiquitin-like protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:22:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:52:28 2008''

Revision as of 06:52, 29 July 2008

File:2c7h.png

Template:STRUCTURE 2c7h

SOLUTION NMR STRUCTURE OF THE DWNN DOMAIN FROM HUMAN RBBP6

Template:ABSTRACT PUBMED 16396680

About this Structure

2C7H is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways., Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ, BMC Struct Biol. 2006 Jan 5;6:1. PMID:16396680

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