2bn0: Difference between revisions

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[[Image:2bn0.gif|left|200px]]
{{Seed}}
[[Image:2bn0.png|left|200px]]


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{{STRUCTURE_2bn0|  PDB=2bn0  |  SCENE=  }}  
{{STRUCTURE_2bn0|  PDB=2bn0  |  SCENE=  }}  


'''BANANA LECTIN BOUND TO LAMINARIBIOSE'''
===BANANA LECTIN BOUND TO LAMINARIBIOSE===




==Overview==
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Banana lectin (Banlec) is a dimeric plant lectin from the jacalin-related lectin family. Banlec belongs to a subgroup of this family that binds to glucose/mannose, but is unique in recognizing internal alpha1,3 linkages as well as beta1,3 linkages at the reducing termini. Here we present the crystal structures of Banlec alone and with laminaribiose (LAM) (Glcbeta1, 3Glc) and Xyl-beta1,3-Man-alpha-O-Methyl. The structure of Banlec has a beta-prism-I fold, similar to other family members, but differs from them in its mode of sugar binding. The reducing unit of the sugar is inserted into the binding site causing the second saccharide unit to be placed in the opposite orientation compared with the other ligand-bound structures of family members. More importantly, our structures reveal the presence of a second sugar binding site that has not been previously reported in the literature. The residues involved in the second site are common to other lectins in this family, potentially signaling a new group of mannose-specific jacalin-related lectins (mJRL) with two sugar binding sites.
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{{ABSTRACT_PUBMED_15944373}}


==About this Structure==
==About this Structure==
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[[Category: Lectin]]
[[Category: Lectin]]
[[Category: Mannose-specific jacalin-related lectin]]
[[Category: Mannose-specific jacalin-related lectin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:31:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:54:59 2008''

Revision as of 06:55, 29 July 2008

File:2bn0.png

Template:STRUCTURE 2bn0

BANANA LECTIN BOUND TO LAMINARIBIOSE

Template:ABSTRACT PUBMED 15944373

About this Structure

2BN0 is a Single protein structure of sequence from Musa acuminata. Full crystallographic information is available from OCA.

Reference

Crystal structure of banana lectin reveals a novel second sugar binding site., Meagher JL, Winter HC, Ezell P, Goldstein IJ, Stuckey JA, Glycobiology. 2005 Oct;15(10):1033-42. Epub 2005 Jun 8. PMID:15944373

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