1rgx: Difference between revisions

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[[Image:1rgx.gif|left|200px]]
{{Seed}}
[[Image:1rgx.png|left|200px]]


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{{STRUCTURE_1rgx|  PDB=1rgx  |  SCENE=  }}  
{{STRUCTURE_1rgx|  PDB=1rgx  |  SCENE=  }}  


'''Crystal Structure of resisitin'''
===Crystal Structure of resisitin===




==Overview==
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Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and diabetes. Crystal structures of resistin and RELMbeta reveal an unusual multimeric structure. Each protomer comprises a carboxy-terminal disulfide-rich beta-sandwich "head" domain and an amino-terminal alpha-helical "tail" segment. The alpha-helical segments associate to form three-stranded coiled coils, and surface-exposed interchain disulfide linkages mediate the formation of tail-to-tail hexamers. Analysis of serum samples shows that resistin circulates in two distinct assembly states, likely corresponding to hexamers and trimers. Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin. This result suggests that processing of the intertrimer disulfide bonds may reflect an obligatory step toward activation.
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{{ABSTRACT_PUBMED_15155948}}


==About this Structure==
==About this Structure==
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[[Category: Resistin/fizz family]]
[[Category: Resistin/fizz family]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:28:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:56:44 2008''

Revision as of 06:56, 29 July 2008

File:1rgx.png

Template:STRUCTURE 1rgx

Crystal Structure of resisitin

Template:ABSTRACT PUBMED 15155948

About this Structure

1RGX is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Disulfide-dependent multimeric assembly of resistin family hormones., Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L, Science. 2004 May 21;304(5674):1154-8. PMID:15155948

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