1qfb: Difference between revisions

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[[Image:1qfb.jpg|left|200px]]
{{Seed}}
[[Image:1qfb.png|left|200px]]


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{{STRUCTURE_1qfb|  PDB=1qfb  |  SCENE=  }}  
{{STRUCTURE_1qfb|  PDB=1qfb  |  SCENE=  }}  


'''THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS'''
===THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS===




==Overview==
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Contryphan-R is a disulfide-constrained octapeptide containing a D-tryptophan that was isolated recently from venom of the cone shell Conus radiatus. The polypeptide is present in two forms in solution due to cis-trans isomerization at hydroxyproline 3. The solution structure of the major form of this unusual polypeptide, determined from NMR data, consists of a well-defined fold containing a non-hydrogen-bonded chain reversal from Gly1 to Glu5, which includes a cis-hydroxyproline and a D-Trp, and a type I beta-turn from Glu5 to Cys8. The presence of a putative salt bridge between the Glu5 carboxyl group and the N-terminal ammonium group is investigated by using various solvation models during energy minimization and is compared with the results of a pH titration. A comparison of the structure of contryphan-R with other cyclic peptide structures highlights some of the key structural determinants of these peptides and suggests that the contryphan-R fold could be exploited as a scaffold onto which unrelated protein binding surfaces could be grafted. Comparison with small disulfide-bridged loops in larger proteins shows that contryphan-R is similar to a commonly occurring loop structure found in proteins.
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{{ABSTRACT_PUBMED_10471307}}


==About this Structure==
==About this Structure==
1QFB is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFB OCA].  
1QFB is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QFB OCA].  


==Reference==
==Reference==
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[[Category: Stiff-tail syndrome]]
[[Category: Stiff-tail syndrome]]
[[Category: Venom duct peptide]]
[[Category: Venom duct peptide]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:11:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:10:36 2008''

Revision as of 07:10, 29 July 2008

File:1qfb.png

Template:STRUCTURE 1qfb

THE CYCLIC PEPTIDE CONTRYPHAN-R FROM CONUS RADIATUS

Template:ABSTRACT PUBMED 10471307

About this Structure

1QFB is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops., Pallaghy PK, Melnikova AP, Jimenez EC, Olivera BM, Norton RS, Biochemistry. 1999 Aug 31;38(35):11553-9. PMID:10471307

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