2eb7: Difference between revisions

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[[Image:2eb7.~~jpg~~|left|200px]]

[[Image:2eb7.png|left|200px]]

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~~'''~~Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7~~'''~~

===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===

~~==Overview==~~

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The ~~emergence of bacterial resistance~~ to ~~multiple drugs poses a serious and growing health concern. Understanding and deciphering~~ the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.~~80 and 2~~.0A, ~~respectively. The overall structure of the ST1710 dimer shares the topology of~~ the ~~MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif~~. ~~We also show the protein~~-~~DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein~~-~~DNA interactions.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17933554}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17933554 is the PubMed ID number.

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==About this Structure==

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[[Category: Structural genomic]]

[[Category: Transcription regulator]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 02~~:16~~:10~~ 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:30:16 2008''

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-[[Image:2eb7.jpg|left|200px]]
+{{Seed}}
+[[Image:2eb7.png|left|200px]]
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 {{STRUCTURE_2eb7|  PDB=2eb7  |  SCENE=  }}
-'''Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7'''
+===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===
-==Overview==
+<!--
-The emergence of bacterial resistance to multiple drugs poses a serious and growing health concern. Understanding and deciphering the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.80 and 2.0A, respectively. The overall structure of the ST1710 dimer shares the topology of the MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif. We also show the protein-DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein-DNA interactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_17933554}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17933554 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17933554}}
 ==About this Structure==
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 [[Category: Structural genomic]]
 [[Category: Transcription regulator]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 02:16:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:30:16 2008''