2gj7: Difference between revisions

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[[Image:2gj7.gif|left|200px]]
{{Seed}}
[[Image:2gj7.png|left|200px]]


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{{STRUCTURE_2gj7|  PDB=2gj7  |  SCENE=  }}  
{{STRUCTURE_2gj7|  PDB=2gj7  |  SCENE=  }}  


'''Crystal Structure of a gE-gI/Fc complex'''
===Crystal Structure of a gE-gI/Fc complex===




==Overview==
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Herpes simplex virus type-1 expresses a heterodimeric Fc receptor, gE-gI, on the surfaces of virions and infected cells that binds the Fc region of host immunoglobulin G and is implicated in the cell-to-cell spread of virus. gE-gI binds immunoglobulin G at the basic pH of the cell surface and releases it at the acidic pH of lysosomes, consistent with a role in facilitating the degradation of antiviral antibodies. Here we identify the C-terminal domain of the gE ectodomain (CgE) as the minimal Fc-binding domain and present a 1.78-angstroms CgE structure. A 5-angstroms gE-gI/Fc crystal structure, which was independently verified by a theoretical prediction method, reveals that CgE binds Fc at the C(H)2-C(H)3 interface, the binding site for several mammalian and bacterial Fc-binding proteins. The structure identifies interface histidines that may confer pH-dependent binding and regions of CgE implicated in cell-to-cell spread of virus. The ternary organization of the gE-gI/Fc complex is compatible with antibody bipolar bridging, which can interfere with the antiviral immune response.
The line below this paragraph, {{ABSTRACT_PUBMED_16646632}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16646632 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16646632}}


==About this Structure==
==About this Structure==
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[[Category: Fc receptor]]
[[Category: Fc receptor]]
[[Category: Low resolution]]
[[Category: Low resolution]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:10:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:39:10 2008''

Revision as of 07:39, 29 July 2008

File:2gj7.png

Template:STRUCTURE 2gj7

Crystal Structure of a gE-gI/Fc complex

Template:ABSTRACT PUBMED 16646632

About this Structure

2GJ7 is a Protein complex structure of sequences from Cricetulus griseus, Homo sapiens and Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging., Sprague ER, Wang C, Baker D, Bjorkman PJ, PLoS Biol. 2006 Jun;4(6):e148. Epub 2006 May 2. PMID:16646632

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