2q7m: Difference between revisions

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[[Image:2q7m.jpg|left|200px]]
{{Seed}}
[[Image:2q7m.png|left|200px]]


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{{STRUCTURE_2q7m|  PDB=2q7m  |  SCENE=  }}  
{{STRUCTURE_2q7m|  PDB=2q7m  |  SCENE=  }}  


'''Crystal structure of human FLAP with MK-591'''
===Crystal structure of human FLAP with MK-591===




==Overview==
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Leukotrienes are proinflammatory products of arachidonic acid oxidation by 5-lipoxygenase that have been shown to be involved in respiratory and cardiovascular diseases. The integral membrane protein FLAP is essential for leukotriene biosynthesis. We describe the x-ray crystal structures of human FLAP in complex with two leukotriene biosynthesis inhibitors at 4.0 and 4.2 angstrom resolution, respectively. The structures show that inhibitors bind in membrane-embedded pockets of FLAP, which suggests how these inhibitors prevent arachidonic acid from binding to FLAP and subsequently being transferred to 5-lipoxygenase, thereby preventing leukotriene biosynthesis. This structural information provides a platform for the development of therapeutics for respiratory and cardiovascular diseases.
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{{ABSTRACT_PUBMED_17600184}}


==About this Structure==
==About this Structure==
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[[Category: Mapeg]]
[[Category: Mapeg]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:29:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:55:40 2008''

Revision as of 07:55, 29 July 2008

File:2q7m.png

Template:STRUCTURE 2q7m

Crystal structure of human FLAP with MK-591

Template:ABSTRACT PUBMED 17600184

About this Structure

2Q7M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein., Ferguson AD, McKeever BM, Xu S, Wisniewski D, Miller DK, Yamin TT, Spencer RH, Chu L, Ujjainwalla F, Cunningham BR, Evans JF, Becker JW, Science. 2007 Jul 27;317(5837):510-2. Epub 2007 Jun 28. PMID:17600184

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