1ng4: Difference between revisions

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[[Image:1ng4.jpg|left|200px]]
{{Seed}}
[[Image:1ng4.png|left|200px]]


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{{STRUCTURE_1ng4|  PDB=1ng4  |  SCENE=  }}  
{{STRUCTURE_1ng4|  PDB=1ng4  |  SCENE=  }}  


'''Structure of ThiO (glycine oxidase) from Bacillus subtilis'''
===Structure of ThiO (glycine oxidase) from Bacillus subtilis===




==Overview==
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The thiO gene of Bacillus subtilis encodes an FAD-dependent glycine oxidase. This enzyme is a homotetramer with a monomer molecular mass of 42 kDa. In this paper, we demonstrate that ThiO is required for the biosynthesis of the thiazole moiety of thiamin pyrophosphate and describe the structure of the enzyme with N-acetylglycine bound at the active site. The closest structural relatives of ThiO are sarcosine oxidase and d-amino acid oxidase. The ThiO structure, as well as the observation that N-cyclopropylglycine is a good substrate, supports a hydride transfer mechanism for the enzyme. A mechanistic proposal for the role of ThiO in thiazole biosynthesis is also described.
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{{ABSTRACT_PUBMED_12627963}}


==About this Structure==
==About this Structure==
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[[Category: Flavoprotein]]
[[Category: Flavoprotein]]
[[Category: Oxidase]]
[[Category: Oxidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:29:23 2008''
 
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