2gv5: Difference between revisions

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[[Image:2gv5.gif|left|200px]]
{{Seed}}
[[Image:2gv5.png|left|200px]]


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{{STRUCTURE_2gv5|  PDB=2gv5  |  SCENE=  }}  
{{STRUCTURE_2gv5|  PDB=2gv5  |  SCENE=  }}  


'''crystal structure of Sfi1p/Cdc31p complex'''
===crystal structure of Sfi1p/Cdc31p complex===




==Overview==
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Centrins are calmodulin-like proteins present in centrosomes and yeast spindle pole bodies (SPBs) and have essential functions in their duplication. The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled. The crystal structures of Sfi1p-centrin complexes containing several repeats show Sfi1p as an alpha helix with centrins wrapped around each repeat and similar centrin-centrin contacts between each repeat. Electron microscopy (EM) shadowing of an Sfi1p-centrin complex with 15 Sfi1 repeats and 15 centrins bound showed filaments 60 nm long, compatible with all the Sfi1 repeats as a continuous alpha helix. Immuno-EM localization of the Sfi1p N and C termini showed Sfi1p-centrin filaments spanning the length of the half-bridge with the Sfi1p N terminus at the SPB. This suggests a model for SPB duplication where the half-bridge doubles in length by association of the Sfi1p C termini, thereby providing a new Sfi1p N terminus to initiate SPB assembly.
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{{ABSTRACT_PUBMED_16785321}}


==About this Structure==
==About this Structure==
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[[Category: Sfi1p]]
[[Category: Sfi1p]]
[[Category: Spindle pole body]]
[[Category: Spindle pole body]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:34:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:30:27 2008''

Revision as of 08:30, 29 July 2008

File:2gv5.png

Template:STRUCTURE 2gv5

crystal structure of Sfi1p/Cdc31p complex

Template:ABSTRACT PUBMED 16785321

About this Structure

2GV5 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication., Li S, Sandercock AM, Conduit P, Robinson CV, Williams RL, Kilmartin JV, J Cell Biol. 2006 Jun 19;173(6):867-77. PMID:16785321

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