2pmp: Difference between revisions

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[[Image:2pmp.~~jpg~~|left|200px]]

[[Image:2pmp.png|left|200px]]

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~~'''~~Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of Arabidopsis thaliana~~'''~~

===Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of Arabidopsis thaliana===

~~==Overview==~~

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The ~~X-ray crystal structure of~~ the ~~2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase~~ (~~MCS) from Arabidopsis thaliana has been solved~~ at 2.~~3 A resolution in complex with a cytidine-5-monophosphate (CMP~~) ~~molecule. This~~ is the ~~first structure determined of an MCS enzyme from a plant~~. Major differences between the A. thaliana and bacterial MCS structures are found in the large molecular cavity that forms between subunits and involve residues that are highly conserved among plants. In some bacterial enzymes, the corresponding cavity has been shown to be an isoprenoid diphosphate-~~like binding pocket, with a proposed feedback~~-regulatory role. Instead, in the structure from A. thaliana the cavity is unsuited for binding a diphosphate moiety, which suggests a different regulatory mechanism of MCS enzymes between bacteria and plants.

The line below this paragraph, {{ABSTRACT_PUBMED_17660251}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17660251 is the PubMed ID number.

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==About this Structure==

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[[Category: Plant enzyme]]

[[Category: Zinc ion]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 13~~:25:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:42:02 2008''

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-[[Image:2pmp.jpg|left|200px]]
+{{Seed}}
+[[Image:2pmp.png|left|200px]]
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 {{STRUCTURE_2pmp|  PDB=2pmp  |  SCENE=  }}
-'''Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of Arabidopsis thaliana'''
+===Structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from the isoprenoid biosynthetic pathway of Arabidopsis thaliana===
-==Overview==
+<!--
-The X-ray crystal structure of the 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MCS) from Arabidopsis thaliana has been solved at 2.3 A resolution in complex with a cytidine-5-monophosphate (CMP) molecule. This is the first structure determined of an MCS enzyme from a plant. Major differences between the A. thaliana and bacterial MCS structures are found in the large molecular cavity that forms between subunits and involve residues that are highly conserved among plants. In some bacterial enzymes, the corresponding cavity has been shown to be an isoprenoid diphosphate-like binding pocket, with a proposed feedback-regulatory role. Instead, in the structure from A. thaliana the cavity is unsuited for binding a diphosphate moiety, which suggests a different regulatory mechanism of MCS enzymes between bacteria and plants.
+The line below this paragraph, {{ABSTRACT_PUBMED_17660251}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17660251 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17660251}}
 ==About this Structure==
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 [[Category: Plant enzyme]]
 [[Category: Zinc ion]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:25:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:42:02 2008''