2icw: Difference between revisions

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[[Image:2icw.gif|left|200px]]
{{Seed}}
[[Image:2icw.png|left|200px]]


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{{STRUCTURE_2icw|  PDB=2icw  |  SCENE=  }}  
{{STRUCTURE_2icw|  PDB=2icw  |  SCENE=  }}  


'''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''
===Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule===




==Overview==
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'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
The line below this paragraph, {{ABSTRACT_PUBMED_17220897}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17220897 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17220897}}


==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Tcr]]
[[Category: Tcr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:20:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:43:08 2008''
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