1w8m: Difference between revisions

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[[Image:1w8m.jpg|left|200px]]
{{Seed}}
[[Image:1w8m.png|left|200px]]


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{{STRUCTURE_1w8m|  PDB=1w8m  |  SCENE=  }}  
{{STRUCTURE_1w8m|  PDB=1w8m  |  SCENE=  }}  


'''ENZYMATIC AND STRUCTURAL CHARACTERISATION OF NON PEPTIDE LIGAND CYCLOPHILIN COMPLEXES'''
===ENZYMATIC AND STRUCTURAL CHARACTERISATION OF NON PEPTIDE LIGAND CYCLOPHILIN COMPLEXES===




==Overview==
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Piperidine ligands are described that provide the first examples of non-peptidic ligand structures for the cyclophilin family of proteins. Crystal structures of two ligand complexes are compared with the unliganded protein and show ligand-induced changes in side-chain conformation and water binding. A peptidylprolyl cis-trans-isomerase assay showed the dissociation constants of the two ligands to be 320 and 25 mM. This study also provides the first published data for both enzymatic activity and three-dimensional structure for any protein-ligand complex that binds with a high-millimolar dissociation constant. The structures may be of relevance in the field of drug design, as they suggest starting points for the design of larger tighter-binding analogues.
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{{ABSTRACT_PUBMED_14993672}}


==About this Structure==
==About this Structure==
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[[Category: Non peptide ligand]]
[[Category: Non peptide ligand]]
[[Category: Rotamase]]
[[Category: Rotamase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:18:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:58:09 2008''

Revision as of 08:58, 29 July 2008

File:1w8m.png

Template:STRUCTURE 1w8m

ENZYMATIC AND STRUCTURAL CHARACTERISATION OF NON PEPTIDE LIGAND CYCLOPHILIN COMPLEXES

Template:ABSTRACT PUBMED 14993672

About this Structure

1W8M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Enzymatic and structural characterization of non-peptide ligand-cyclophilin complexes., Kontopidis G, Taylor P, Walkinshaw MD, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):479-85. Epub 2004, Feb 25. PMID:14993672

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