2fa2: Difference between revisions

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[[Image:2fa2.~~gif~~|left|200px]]

[[Image:2fa2.png|left|200px]]

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~~'''~~Crystal structure of Fus3 without a peptide from Ste5~~'''~~

===Crystal structure of Fus3 without a peptide from Ste5===

~~==Overview==~~

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~~Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that~~ the ~~Ste5 scaffold has a more active role in~~ the ~~yeast mating pathway~~: ~~A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3~~. ~~The resulting form of Fus3~~ is ~~partially active-it is phosphorylated on only one of two key residues in~~ the ~~activation loop~~. Unexpectedly, at a systems level, autoactivated Fus3 appears to have a negative regulatory role, promoting Ste5 phosphorylation and a decrease in pathway transcriptional output. Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-~~output properties.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16424299}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16424299 is the PubMed ID number.

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==About this Structure==

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[[Category: Remenyi, A.]]

[[Category: Map kinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 03~~:38:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:10:10 2008''

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-[[Image:2fa2.gif|left|200px]]
+{{Seed}}
+[[Image:2fa2.png|left|200px]]
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 {{STRUCTURE_2fa2|  PDB=2fa2  |  SCENE=  }}
-'''Crystal structure of Fus3 without a peptide from Ste5'''
+===Crystal structure of Fus3 without a peptide from Ste5===
-==Overview==
+<!--
-Scaffold proteins organize signaling proteins into pathways and are often viewed as passive assembly platforms. We found that the Ste5 scaffold has a more active role in the yeast mating pathway: A fragment of Ste5 allosterically activated autophosphorylation of the mitogen-activated protein kinase Fus3. The resulting form of Fus3 is partially active-it is phosphorylated on only one of two key residues in the activation loop. Unexpectedly, at a systems level, autoactivated Fus3 appears to have a negative regulatory role, promoting Ste5 phosphorylation and a decrease in pathway transcriptional output. Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties.
+The line below this paragraph, {{ABSTRACT_PUBMED_16424299}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16424299 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16424299}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Remenyi, A.]]
 [[Category: Map kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:38:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:10:10 2008''