2ntn: Difference between revisions

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[[Image:2ntn.gif|left|200px]]
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{{STRUCTURE_2ntn|  PDB=2ntn  |  SCENE=  }}  
{{STRUCTURE_2ntn|  PDB=2ntn  |  SCENE=  }}  


'''Crystal structure of MabA-C60V/G139A/S144L'''
===Crystal structure of MabA-C60V/G139A/S144L===




==Overview==
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The MabA protein from Mycobacterium tuberculosis is a validated drug target. Previous structural studies of this protein showed dynamic behaviour in the catalytic site and described motion between an open 'active' holo form (with NADP) and a closed 'inactive' apo form (without NADP). Here, a mutation (G139A) is reported that leads to complete protein inactivation and freezes the catalytic site into its closed form, even in the presence of the cofactor. This observation suggests a new way to develop anti-MabA drugs via protein stabilization of the 'inactive' form.
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{{ABSTRACT_PUBMED_17642518}}


==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Sdr]]
[[Category: Sdr]]
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Revision as of 09:24, 29 July 2008

File:2ntn.png

Template:STRUCTURE 2ntn

Crystal structure of MabA-C60V/G139A/S144L

Template:ABSTRACT PUBMED 17642518

About this Structure

2NTN is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies., Poncet-Montange G, Ducasse-Cabanot S, Quemard A, Labesse G, Cohen-Gonsaud M, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):923-5. Epub 2007, Jul 17. PMID:17642518

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