2h0q: Difference between revisions

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[[Image:2h0q.jpg|left|200px]]
{{Seed}}
[[Image:2h0q.png|left|200px]]


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{{STRUCTURE_2h0q|  PDB=2h0q  |  SCENE=  }}  
{{STRUCTURE_2h0q|  PDB=2h0q  |  SCENE=  }}  


'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''
===Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)===




==Overview==
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Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.
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{{ABSTRACT_PUBMED_17679096}}


==About this Structure==
==About this Structure==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Sts-1]]
[[Category: Sts-1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:43:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:42:21 2008''

Revision as of 09:42, 29 July 2008

File:2h0q.png

Template:STRUCTURE 2h0q

Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)

Template:ABSTRACT PUBMED 17679096

About this Structure

2H0Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096

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