3biw: Difference between revisions

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[[Image:3biw.jpg|left|200px]]
{{Seed}}
[[Image:3biw.png|left|200px]]


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{{STRUCTURE_3biw|  PDB=3biw  |  SCENE=  }}  
{{STRUCTURE_3biw|  PDB=3biw  |  SCENE=  }}  


'''Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex'''
===Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex===




==Overview==
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Neurexins and neuroligins provide trans-synaptic connectivity by the Ca2+-dependent interaction of their alternatively spliced extracellular domains. Neuroligins specify synapses in an activity-dependent manner, presumably by binding to neurexins. Here, we present the crystal structures of neuroligin-1 in isolation and in complex with neurexin-1 beta. Neuroligin-1 forms a constitutive dimer, and two neurexin-1 beta monomers bind to two identical surfaces on the opposite faces of the neuroligin-1 dimer to form a heterotetramer. The neuroligin-1/neurexin-1 beta complex exhibits a nanomolar affinity and includes a large binding interface that contains bound Ca2+. Alternatively spliced sites in neurexin-1 beta and in neuroligin-1 are positioned nearby the binding interface, explaining how they regulate the interaction. Structure-based mutations of neuroligin-1 at the interface disrupt binding to neurexin-1 beta, but not the folding of neuroligin-1 and confirm the validity of the binding interface of the neuroligin-1/neurexin-1 beta complex. Our results provide molecular insights for understanding the role of cell-adhesion proteins in synapse function.
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{{ABSTRACT_PUBMED_18093522}}


==About this Structure==
==About this Structure==
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[[Category: Synapse]]
[[Category: Synapse]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:49:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:45:18 2008''

Revision as of 09:45, 29 July 2008

File:3biw.png

Template:STRUCTURE 3biw

Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex

Template:ABSTRACT PUBMED 18093522

About this Structure

3BIW is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions., Arac D, Boucard AA, Ozkan E, Strop P, Newell E, Sudhof TC, Brunger AT, Neuron. 2007 Dec 20;56(6):992-1003. PMID:18093522

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