2q1v: Difference between revisions

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[[Image:2q1v.~~jpg~~|left|200px]]

[[Image:2q1v.png|left|200px]]

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~~'''~~Ancestral corticoid receptor in complex with cortisol~~'''~~

===Ancestral corticoid receptor in complex with cortisol===

~~==Overview==~~

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The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucocorticoid (GR) and mineralocorticoid (MR) receptors. Using structural, phylogenetic, ~~and functional analysis~~, ~~we identify~~ the ~~specific set of historical mutations that recapitulate~~ the ~~evolution of GR's hormone specificity from an MR-like ancestor~~. ~~These substitutions repositioned crucial residues to create new receptor-ligand and intraprotein contacts~~. ~~Strong epistatic interactions occur because one substitution changes~~ the ~~conformational position of another site~~. ~~"Permissive" mutations~~-~~substitutions of no immediate consequence, which stabilize specific elements of the protein and allow it to tolerate subsequent function~~-~~switching changes-played a major role in determining GR's evolutionary trajectory.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17702911}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17702911 is the PubMed ID number.

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==About this Structure==

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[[Category: Nuclear receptor]]

[[Category: Transcription]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 14~~:11:22 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:55:29 2008''

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-[[Image:2q1v.jpg|left|200px]]
+{{Seed}}
+[[Image:2q1v.png|left|200px]]
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 {{STRUCTURE_2q1v|  PDB=2q1v  |  SCENE=  }}
-'''Ancestral corticoid receptor in complex with cortisol'''
+===Ancestral corticoid receptor in complex with cortisol===
-==Overview==
+<!--
-The structural mechanisms by which proteins have evolved new functions are known only indirectly. We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucocorticoid (GR) and mineralocorticoid (MR) receptors. Using structural, phylogenetic, and functional analysis, we identify the specific set of historical mutations that recapitulate the evolution of GR's hormone specificity from an MR-like ancestor. These substitutions repositioned crucial residues to create new receptor-ligand and intraprotein contacts. Strong epistatic interactions occur because one substitution changes the conformational position of another site. "Permissive" mutations-substitutions of no immediate consequence, which stabilize specific elements of the protein and allow it to tolerate subsequent function-switching changes-played a major role in determining GR's evolutionary trajectory.
+The line below this paragraph, {{ABSTRACT_PUBMED_17702911}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17702911 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17702911}}
 ==About this Structure==
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 [[Category: Nuclear receptor]]
 [[Category: Transcription]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:11:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:55:29 2008''