2hc4: Difference between revisions

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[[Image:2hc4.jpg|left|200px]]
{{Seed}}
[[Image:2hc4.png|left|200px]]


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{{STRUCTURE_2hc4|  PDB=2hc4  |  SCENE=  }}  
{{STRUCTURE_2hc4|  PDB=2hc4  |  SCENE=  }}  


'''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''
===Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol===




==Overview==
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The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.
The line below this paragraph, {{ABSTRACT_PUBMED_17218092}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17218092}}


==About this Structure==
==About this Structure==
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[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
[[Category: Alpha helical sandwich]]
[[Category: Alpha helical sandwich]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:06:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:07:09 2008''
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