1soh: Difference between revisions

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[[Image:1soh.gif|left|200px]]
{{Seed}}
[[Image:1soh.png|left|200px]]


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{{STRUCTURE_1soh|  PDB=1soh  |  SCENE=  }}  
{{STRUCTURE_1soh|  PDB=1soh  |  SCENE=  }}  


'''The structure of human apolipoprotein C-II in dodecyl phosphocholine'''
===The structure of human apolipoprotein C-II in dodecyl phosphocholine===




==Overview==
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The structure of human apolipoprotein C-II (apoC-II) in the presence of dodecyl phosphocholine (DPC) micelles has been investigated by NMR spectroscopy. The resulting structural information is compared to that available for apoC-II in the presence of sodium dodecyl sulfate, revealing a high level of overall similarity but several significant differences. These findings further our understandings of the structural basis for apoC-II function. The interactions of the protein with the detergent micelle are probed using intermolecular nuclear Overhauser effects (NOEs) and paramagnetic agents. These interactions are seen across almost the full length of apoC-II and show the periodicity expected for an amphipathic helix interacting with the amphipathic surface of the DPC micelle. Furthermore, we observe specific contacts between lysine residues of apoC-II and protons near the phosphate group of DPC, consistent with the predictions of the so-called "snorkel hypothesis" of the structural basis for the apolipoprotein/lipid interaction (Segrest, J. P., Jackson, R. L., Morrisett, J. D., and Gotto, A. M., Jr. (1974) A molecular theory of lipid-protein interactions in the plasma lipoproteins, FEBS Lett 38, 247-258.). These findings offer the most detailed structural information available for the interaction between an apolipoprotein and the phospholipids of the lipoprotein surface and provide the first direct structural support for the snorkel hypothesis.
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{{ABSTRACT_PUBMED_15209504}}


==Disease==
==Disease==
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==About this Structure==
==About this Structure==
1SOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOH OCA].  
1SOH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOH OCA].  


==Reference==
==Reference==
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[[Category: MacRaild, C A.]]
[[Category: MacRaild, C A.]]
[[Category: Lipid transport]]
[[Category: Lipid transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:57:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:08:00 2008''

Revision as of 10:08, 29 July 2008

File:1soh.png

Template:STRUCTURE 1soh

The structure of human apolipoprotein C-II in dodecyl phosphocholine

Template:ABSTRACT PUBMED 15209504

Disease

Known disease associated with this structure: Hyperlipoproteinemia, type Ib OMIM:[608083]

About this Structure

1SOH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure and interactions of human apolipoprotein C-II in dodecyl phosphocholine., MacRaild CA, Howlett GJ, Gooley PR, Biochemistry. 2004 Jun 29;43(25):8084-93. PMID:15209504

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