3bug: Difference between revisions

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-[[Image:3bug.jpg|left|200px]]
+{{Seed}}
+[[Image:3bug.png|left|200px]]
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 {{STRUCTURE_3bug|  PDB=3bug  |  SCENE=  }}
-'''BACE-1 complexed with compound 3'''
+===BACE-1 complexed with compound 3===
-==Overview==
+<!--
-Fragment screening revealed that tyramine binds to the active site of the Alzheimer's disease drug target BACE-1. Hit expansion by selection of compounds from the Roche compound library identified tyramine derivatives with improved binding affinities as monitored by surface plasmon resonance. X-ray structures show that the amine of the tyramine fragment hydrogen-bonds to the catalytic water molecule. Structure-guided ligand design led to the synthesis of further low molecular weight compounds that are starting points for chemical leads.
+The line below this paragraph, {{ABSTRACT_PUBMED_18226904}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18226904 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18226904}}
 ==About this Structure==
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 [[Category: Transmembrane]]
 [[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:06:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:10:02 2008''

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