3cqu: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Newer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
New page: left|200px <!-- The line below this paragraph, containing "STRUCTURE_3cqu", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:3cqu.jpg|left|200px]]
{{Seed}}
[[Image:3cqu.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3cqu|  PDB=3cqu  |  SCENE=  }}  
{{STRUCTURE_3cqu|  PDB=3cqu  |  SCENE=  }}  


'''Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor'''
===Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor===




==Overview==
<!--
Based on a high throughput screening hit, pyrrolopyrimidine inhibitors of the Akt kinase are explored. X-ray co-crystal structures of two lead series results in the understanding of key binding interactions, the design of new lead series, and enhanced potency. The syntheses of these series and their biological activities are described. Spiroindoline 13j is found to have an Akt1 kinase IC(50) of 2.4+/-0.6nM, Akt cell potency of 50+/-19nM, and provides 68% inhibition of tumor growth in a mouse xenograft model (50mg/kg, qd, po).
The line below this paragraph, {{ABSTRACT_PUBMED_18456494}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18456494 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_18456494}}


==About this Structure==
==About this Structure==
Line 43: Line 47:
[[Category: Transport]]
[[Category: Transport]]
[[Category: Wnt signaling pathway]]
[[Category: Wnt signaling pathway]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 28 09:22:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:12:06 2008''
Retrieved from "https://proteopedia.org/3cqu"