2v47: Difference between revisions

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[[Image:2v47.~~gif~~|left|200px]]

[[Image:2v47.png|left|200px]]

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~~'''~~STRUCTURE OF THE RIBOSOME RECYCLING FACTOR BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME WITH MRNA, ASL-PHE AND TRNA-FMET (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FOR MOLECULE 1.~~'''~~

===STRUCTURE OF THE RIBOSOME RECYCLING FACTOR BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME WITH MRNA, ASL-PHE AND TRNA-FMET (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FOR MOLECULE 1.===

~~==Overview==~~

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~~In bacteria~~, ~~disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF)~~, ~~which works in concert with elongation factor G. Here we describe the crystal structure of~~ the ~~Thermus thermophilus RRF bound~~ to ~~a 70S ribosomal complex containing a stop codon in~~ the ~~A site, a transfer RNA anticodon stem-loop in the P site and tRNA~~(~~fMet) in the E site~~. ~~The work demonstrates that structures of translation factors bound to 70S ribosomes can be determined at reasonably high resolution~~. ~~Contrary to earlier reports~~, ~~we did not observe any RRF-induced changes in bridges connecting~~ the ~~two subunits. This suggests that such changes are not a direct requirement for or consequence of RRF binding but possibly arise from the subsequent stabilization of a hybrid state of the ribosome~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17660830}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17660830 is the PubMed ID number.

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==About this Structure==

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[[Category: Translation]]

[[Category: Trna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:11:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:17:43 2008''

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-[[Image:2v47.gif|left|200px]]
+{{Seed}}
+[[Image:2v47.png|left|200px]]
 <!--
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 {{STRUCTURE_2v47|  PDB=2v47  |  SCENE=  }}
-'''STRUCTURE OF THE RIBOSOME RECYCLING FACTOR BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME WITH MRNA, ASL-PHE AND TRNA-FMET (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FOR MOLECULE 1.'''
+===STRUCTURE OF THE RIBOSOME RECYCLING FACTOR BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME WITH MRNA, ASL-PHE AND TRNA-FMET (PART 2 OF 4). THIS FILE CONTAINS THE 50S SUBUNIT FOR MOLECULE 1.===
-==Overview==
+<!--
-In bacteria, disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF), which works in concert with elongation factor G. Here we describe the crystal structure of the Thermus thermophilus RRF bound to a 70S ribosomal complex containing a stop codon in the A site, a transfer RNA anticodon stem-loop in the P site and tRNA(fMet) in the E site. The work demonstrates that structures of translation factors bound to 70S ribosomes can be determined at reasonably high resolution. Contrary to earlier reports, we did not observe any RRF-induced changes in bridges connecting the two subunits. This suggests that such changes are not a direct requirement for or consequence of RRF binding but possibly arise from the subsequent stabilization of a hybrid state of the ribosome.
+The line below this paragraph, {{ABSTRACT_PUBMED_17660830}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17660830 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17660830}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Translation]]
 [[Category: Trna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:11:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:17:43 2008''