2d5z: Difference between revisions

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[[Image:2d5z.gif|left|200px]]
{{Seed}}
[[Image:2d5z.png|left|200px]]


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{{STRUCTURE_2d5z|  PDB=2d5z  |  SCENE=  }}  
{{STRUCTURE_2d5z|  PDB=2d5z  |  SCENE=  }}  


'''Crystal structure of T-state human hemoglobin complexed with three L35 molecules'''
===Crystal structure of T-state human hemoglobin complexed with three L35 molecules===




==Overview==
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Although detailed crystal structures of haemoglobin (Hb) provide a clear understanding of the basic allosteric mechanism of the protein, and how this in turn controls oxygen affinity, recent experiments with artificial effector molecules have shown a far greater control of oxygen binding than with natural heterotropic effectors. Contrary to the established text-book view, these non-physiological compounds are able to reduce oxygen affinity very strongly without switching the protein to the T (tense) state. In an earlier paper we showed that bezafibrate (BZF) binds to a surface pocket on the alpha subunits of R state Hb, strongly reducing the oxygen affinity of this protein conformation. Here we report the crystallisation of Hb with L35, a related compound, and show that this binds to the central cavity of both R and T state Hb. The mechanism by which L35 reduces oxygen affinity is discussed, in relation to spectroscopic studies of effector binding.
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{{ABSTRACT_PUBMED_16403522}}


==About this Structure==
==About this Structure==
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[[Category: Hemoglobin]]
[[Category: Hemoglobin]]
[[Category: L35]]
[[Category: L35]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:45:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:20:42 2008''

Revision as of 10:20, 29 July 2008

File:2d5z.png

Template:STRUCTURE 2d5z

Crystal structure of T-state human hemoglobin complexed with three L35 molecules

Template:ABSTRACT PUBMED 16403522

About this Structure

2D5Z is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

R-state haemoglobin with low oxygen affinity: crystal structures of deoxy human and carbonmonoxy horse haemoglobin bound to the effector molecule L35., Yokoyama T, Neya S, Tsuneshige A, Yonetani T, Park SY, Tame JR, J Mol Biol. 2006 Feb 24;356(3):790-801. Epub 2005 Dec 21. PMID:16403522

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