2dff: Difference between revisions

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[[Image:2dff.jpg|left|200px]]
{{Seed}}
[[Image:2dff.png|left|200px]]


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{{STRUCTURE_2dff|  PDB=2dff  |  SCENE=  }}  
{{STRUCTURE_2dff|  PDB=2dff  |  SCENE=  }}  


'''Crystal structure of Tk-RNase HII(1-204)-C'''
===Crystal structure of Tk-RNase HII(1-204)-C===




==Overview==
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Certain sequences, known as chameleon sequences, take both alpha- and beta-conformations in natural proteins. We demonstrate that a wild chameleon sequence fused to the C-terminal alpha-helix or beta-sheet in foreign stable proteins from hyperthermophiles forms the same conformation as the host secondary structure. However, no secondary structural formation is observed when the sequence is attached to the outside of the secondary structure. These results indicate that this sequence inherently possesses an ability to make either alpha- or beta-conformation, depending on the sequentially neighboring secondary structure if little other nonlocal interaction occurs. Thus, chameleon sequences take on a satellite state through contagion by the power of a secondary structure. We propose this "conformational contagion" as a new nonlocal determinant factor in protein structure and misfolding related to protein conformational diseases.
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{{ABSTRACT_PUBMED_17510955}}


==About this Structure==
==About this Structure==
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[[Category: Ribonuclease hii]]
[[Category: Ribonuclease hii]]
[[Category: Thermococcus kodakaraensis]]
[[Category: Thermococcus kodakaraensis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 00:19:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:29:09 2008''

Revision as of 10:29, 29 July 2008

File:2dff.png

Template:STRUCTURE 2dff

Crystal structure of Tk-RNase HII(1-204)-C

Template:ABSTRACT PUBMED 17510955

About this Structure

2DFF is a Single protein structure of sequence from Thermococcus kodakarensis. Full crystallographic information is available from OCA.

Reference

Conformational contagion in a protein: structural properties of a chameleon sequence., Takano K, Katagiri Y, Mukaiyama A, Chon H, Matsumura H, Koga Y, Kanaya S, Proteins. 2007 Aug 15;68(3):617-25. PMID:17510955

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