3c2g: Difference between revisions

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[[Image:3c2g.jpg|left|200px]]
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{{STRUCTURE_3c2g|  PDB=3c2g  |  SCENE=  }}  
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'''Crystal complex of SYS-1/POP-1 at 2.5A resolution'''
===Crystal complex of SYS-1/POP-1 at 2.5A resolution===




==Overview==
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C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
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==About this Structure==
==About this Structure==
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[[Category: Pop-1]]
[[Category: Pop-1]]
[[Category: Sys-1]]
[[Category: Sys-1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 21:54:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:32:33 2008''

Revision as of 10:32, 29 July 2008

File:3c2g.png

Template:STRUCTURE 3c2g

Crystal complex of SYS-1/POP-1 at 2.5A resolution

Template:ABSTRACT PUBMED 18477457

About this Structure

3C2G is a Protein complex structure of sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:18477457

Page seeded by OCA on Tue Jul 29 13:32:33 2008

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