2cjm: Difference between revisions

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[[Image:2cjm.gif|left|200px]]
{{Seed}}
[[Image:2cjm.png|left|200px]]


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{{STRUCTURE_2cjm|  PDB=2cjm  |  SCENE=  }}  
{{STRUCTURE_2cjm|  PDB=2cjm  |  SCENE=  }}  


'''MECHANISM OF CDK INHIBITION BY ACTIVE SITE PHOSPHORYLATION: CDK2 Y15P T160P IN COMPLEX WITH CYCLIN A STRUCTURE'''
===MECHANISM OF CDK INHIBITION BY ACTIVE SITE PHOSPHORYLATION: CDK2 Y15P T160P IN COMPLEX WITH CYCLIN A STRUCTURE===




==Overview==
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Inhibition of cyclin-dependent kinase 1 (CDK1) activity by Tyr-15 phosphorylation directly regulates entry into mitosis and is an important element in the control of the unperturbed cell cycle. Active site phosphorylation of other members of the CDK family that regulate cell cycle progression instates checkpoints that are fundamental to eukaryotic cell cycle regulation. Kinetic and crystallographic analyses of CDK2-cyclin A complexes reveal that this inhibitory mechanism operates through steric blockade of peptide substrate binding and through the creation of an environment that favors a non-productive conformation of the terminal group of ATP. By contrast, tyrosine phosphorylation of CDK2 alters neither its Km for ATP nor its significant intrinsic ATPase activity. Tyr-15-phosphorylated CDK2 retains trace protein phosphorylation activity that should be considered in quantitative and qualitative cell cycle models.
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{{ABSTRACT_PUBMED_17095507}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:33:00 2008''

Revision as of 10:33, 29 July 2008

File:2cjm.png

Template:STRUCTURE 2cjm

MECHANISM OF CDK INHIBITION BY ACTIVE SITE PHOSPHORYLATION: CDK2 Y15P T160P IN COMPLEX WITH CYCLIN A STRUCTURE

Template:ABSTRACT PUBMED 17095507

About this Structure

2CJM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A., Welburn JP, Tucker JA, Johnson T, Lindert L, Morgan M, Willis A, Noble ME, Endicott JA, J Biol Chem. 2007 Feb 2;282(5):3173-81. Epub 2006 Nov 9. PMID:17095507

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