1ign: Difference between revisions

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[[Image:1ign.gif|left|200px]]
{{Seed}}
[[Image:1ign.png|left|200px]]


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{{STRUCTURE_1ign|  PDB=1ign  |  SCENE=  }}  
{{STRUCTURE_1ign|  PDB=1ign  |  SCENE=  }}  


'''DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE'''
===DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE===




==Overview==
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Telomeres, the nucleoprotein complexes at the ends of eukaryotic chromosomes, are essential for chromosome stability. In the yeast S. cerevisiae, telomeric DNA is bound in a sequence-specific manner by RAP1, a multifunctional protein also involved in transcriptional regulation. Here we report the crystal structure of the DNA-binding domain of RAP1 in complex with telomeric DNA site at 2.25 A resolution. The protein contains two similar domains that bind DNA in a tandem orientation, recognizing a tandemly repeated DNA sequence. The domains are structurally related to the homeodomain and the proto-oncogene Myb, but show novel features in their DNA-binding mode. A structured linker between the domains and a long C-terminal tail contribute to the binding specificity. This structure provides insight into the recognition of the conserved telomeric DNA sequences by a protein.
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{{ABSTRACT_PUBMED_8620531}}


==About this Structure==
==About this Structure==
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[[Category: Rhodes, D.]]
[[Category: Rhodes, D.]]
[[Category: Rap1,yeast,telomeres,homoeodomain]]
[[Category: Rap1,yeast,telomeres,homoeodomain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:58:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:41:38 2008''

Revision as of 10:41, 29 July 2008

File:1ign.png

Template:STRUCTURE 1ign

DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE

Template:ABSTRACT PUBMED 8620531

About this Structure

1IGN is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA., Konig P, Giraldo R, Chapman L, Rhodes D, Cell. 1996 Apr 5;85(1):125-36. PMID:8620531

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