2v9t: Difference between revisions

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[[Image:2v9t.gif|left|200px]]
{{Seed}}
[[Image:2v9t.png|left|200px]]


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{{STRUCTURE_2v9t|  PDB=2v9t  |  SCENE=  }}  
{{STRUCTURE_2v9t|  PDB=2v9t  |  SCENE=  }}  


'''COMPLEX BETWEEN THE SECOND LRR DOMAIN OF SLIT2 AND THE FIRST IG DOMAIN FROM ROBO1'''
===COMPLEX BETWEEN THE SECOND LRR DOMAIN OF SLIT2 AND THE FIRST IG DOMAIN FROM ROBO1===




==Overview==
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Slits are large multidomain leucine-rich repeat (LRR)-containing proteins that provide crucial guidance cues in neuronal and vascular development. More recently, Slits have been implicated in heart morphogenesis, angiogenesis, and tumor metastasis. Slits are ligands for the Robo (Roundabout) receptors, which belong to the Ig superfamily of transmembrane signaling molecules. The Slit-Robo interaction is mediated by the second LRR domain of Slit and the two N-terminal Ig domains of Robo, but the molecular details of this interaction and how it induces signaling remain unclear. Here we describe the crystal structures of the second LRR domain of human Slit2 (Slit2 D2), the first two Ig domains of its receptor Robo1 (Ig1-2), and the minimal complex between these proteins (Slit2 D2-Robo1 Ig1). Slit2 D2 binds with its concave surface to the side of Ig1 with electrostatic and hydrophobic contact regions mediated by residues that are conserved in other family members. Surface plasmon resonance experiments and a mutational analysis of the interface confirm that Ig1 is the primary domain for binding Slit2. These structures provide molecular insight into Slit-Robo complex formation and will be important for the development of novel cancer therapeutics.
The line below this paragraph, {{ABSTRACT_PUBMED_17848514}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17848514 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17848514}}


==About this Structure==
==About this Structure==
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[[Category: Slit2]]
[[Category: Slit2]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:27:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:49:20 2008''

Revision as of 10:49, 29 July 2008

File:2v9t.png

Template:STRUCTURE 2v9t

COMPLEX BETWEEN THE SECOND LRR DOMAIN OF SLIT2 AND THE FIRST IG DOMAIN FROM ROBO1

Template:ABSTRACT PUBMED 17848514

About this Structure

2V9T is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural insights into the Slit-Robo complex., Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA, Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14923-8. Epub 2007 Sep 11. PMID:17848514

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