2q7r: Difference between revisions

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[[Image:2q7r.jpg|left|200px]]
{{Seed}}
[[Image:2q7r.png|left|200px]]


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{{STRUCTURE_2q7r|  PDB=2q7r  |  SCENE=  }}  
{{STRUCTURE_2q7r|  PDB=2q7r  |  SCENE=  }}  


'''Crystal structure of human FLAP with an iodinated analog of MK-591'''
===Crystal structure of human FLAP with an iodinated analog of MK-591===




==Overview==
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Leukotrienes are proinflammatory products of arachidonic acid oxidation by 5-lipoxygenase that have been shown to be involved in respiratory and cardiovascular diseases. The integral membrane protein FLAP is essential for leukotriene biosynthesis. We describe the x-ray crystal structures of human FLAP in complex with two leukotriene biosynthesis inhibitors at 4.0 and 4.2 angstrom resolution, respectively. The structures show that inhibitors bind in membrane-embedded pockets of FLAP, which suggests how these inhibitors prevent arachidonic acid from binding to FLAP and subsequently being transferred to 5-lipoxygenase, thereby preventing leukotriene biosynthesis. This structural information provides a platform for the development of therapeutics for respiratory and cardiovascular diseases.
The line below this paragraph, {{ABSTRACT_PUBMED_17600184}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17600184}}


==About this Structure==
==About this Structure==
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[[Category: Mapeg]]
[[Category: Mapeg]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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