2b53: Difference between revisions

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[[Image:2b53.gif|left|200px]]
{{Seed}}
[[Image:2b53.png|left|200px]]


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{{STRUCTURE_2b53|  PDB=2b53  |  SCENE=  }}  
{{STRUCTURE_2b53|  PDB=2b53  |  SCENE=  }}  


'''Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325'''
===Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325===




==Overview==
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Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.
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{{ABSTRACT_PUBMED_11354366}}


==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
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