1t4f: Difference between revisions

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[[Image:1t4f.gif|left|200px]]
{{Seed}}
[[Image:1t4f.png|left|200px]]


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{{STRUCTURE_1t4f|  PDB=1t4f  |  SCENE=  }}  
{{STRUCTURE_1t4f|  PDB=1t4f  |  SCENE=  }}  


'''Structure of human MDM2 in complex with an optimized p53 peptide'''
===Structure of human MDM2 in complex with an optimized p53 peptide===




==Overview==
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HDM2 binds to an alpha-helical transactivation domain of p53, inhibiting its tumor suppressive functions. A miniaturized thermal denaturation assay was used to screen chemical libraries, resulting in the discovery of a novel series of benzodiazepinedione antagonists of the HDM2-p53 interaction. The X-ray crystal structure of improved antagonists bound to HDM2 reveals their alpha-helix mimetic properties. These optimized molecules increase the transcription of p53 target genes and decrease proliferation of tumor cells expressing wild-type p53.
The line below this paragraph, {{ABSTRACT_PUBMED_15715460}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15715460 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15715460}}


==About this Structure==
==About this Structure==
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[[Category: Mdm2-p53 peptide complex]]
[[Category: Mdm2-p53 peptide complex]]
[[Category: P53-binding protein mdm2 oncoprotein mdm2 double minute 2 protein hdm2]]
[[Category: P53-binding protein mdm2 oncoprotein mdm2 double minute 2 protein hdm2]]
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