2bxx: Difference between revisions

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[[Image:2bxx.gif|left|200px]]
{{Seed}}
[[Image:2bxx.png|left|200px]]


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{{STRUCTURE_2bxx|  PDB=2bxx  |  SCENE=  }}  
{{STRUCTURE_2bxx|  PDB=2bxx  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF IBV CORONAVIRUS NUCLEOCAPSID. NATIVE CRYSTAL FORM'''
===CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF IBV CORONAVIRUS NUCLEOCAPSID. NATIVE CRYSTAL FORM===




==Overview==
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The coronavirus nucleocapsid (N) protein packages viral genomic RNA into a ribonucleoprotein complex. Interactions between N proteins and RNA are thus crucial for the assembly of infectious virus particles. The 45 kDa recombinant nucleocapsid N protein of coronavirus infectious bronchitis virus (IBV) is highly sensitive to proteolysis. We obtained a stable fragment of 14.7 kDa spanning its N-terminal residues 29-160 (IBV-N29-160). Like the N-terminal RNA binding domain (SARS-N45-181) of the severe acute respiratory syndrome virus (SARS-CoV) N protein, the crystal structure of the IBV-N29-160 fragment at 1.85 A resolution reveals a protein core composed of a five-stranded antiparallel beta sheet with a positively charged beta hairpin extension and a hydrophobic platform that are probably involved in RNA binding. Crosslinking studies demonstrate the formation of dimers, tetramers, and higher multimers of IBV-N. A model for coronavirus shell formation is proposed in which dimerization of the C-terminal domain of IBV-N leads to oligomerization of the IBV-nucleocapsid protein and viral RNA condensation.
The line below this paragraph, {{ABSTRACT_PUBMED_16338414}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16338414}}


==About this Structure==
==About this Structure==
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[[Category: Ooi, A.]]
[[Category: Ooi, A.]]
[[Category: Nucleocapsid protein,phosphorylation,rna-binding,viral nucleoprotein]]
[[Category: Nucleocapsid protein,phosphorylation,rna-binding,viral nucleoprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:56:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:30:35 2008''
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